Records 1-30 (of 56 Records) |
Query Trace: Genetic risk score or polygenic[original query] |
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Canadian COVID-19 host genetics cohort replicates known severity associations. Garg Elika, et al. PLoS genetics 2024 0 0. (3) e1011192 |
COVID-19 lockdown, genetic ADHD susceptibility, and mental health in 10- year-old children. Hernández-Lorca María, et al. Psychiatry research 2023 0 0. 115481 |
How are genetics, lifestyles, and cardiovascular and thromboembolic events associated following COVID-19 diagnosis? TS Lomte, News Medical, August 2023
A recent study published in Nature Communications evaluated the associations between host genetics, lifestyle factors, and cardiovascular and thromboembolic events (CVEs) after coronavirus disease 2019 (COVID-19). Although prophylactic coagulation is recommended for hospitalized COVID-19 patients, mixed evidence exists for milder ambulatory and more critical COVID-19 patients. Polygenic risk scores (PRSs) have been proposed for early risk stratification and precision medicine. Whether genetic susceptibility to chronic CVD predisposes COVID-19 patients to CVE complications is unknown.
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GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein. Gusakova Mariya S, et al. Frontiers in medicine 2023 0 0. 1178939 |
Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection. Xie Junqing, et al. Nature communications 2023 0 0. (1) 4659 |
Genetic Determinants of the Acute Respiratory Distress Syndrome. Suarez-Pajes Eva, et al. Journal of clinical medicine 2023 0 0. (11) |
Assessing the potential of polygenic scores to strengthen medical risk prediction models of COVID-19. Aldo Córdova-Palomera et al. PLoS One 2023 5 (5) e0285991
In UK Biobank participants of European ancestry, the model achieved a relatively high performance (area under the receiver operating characteristic curve ~90%). Polygenic scores for COVID-19 computed from summary statistics of the Covid19 Host Genetics Initiative displayed significant associations with COVID-19 in the UK Biobank (p-values as low as 3.96e-9, all with R2 under 1%), but were unable to robustly improve predictive performance of the non-genetic factors.
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Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19. Zhu Dongliang, et al. Journal of epidemiology and global health 2023 0 0. |
Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders. Waszczuk Monika A, et al. PloS one 2023 0 0. (3) e0282271 |
Polygenic Risk Scores for Asthma and Allergic Disease Associate with COVID-19 Severity in 9/11 Responders M Wasczuk et al, MEDRXIV, February 16, 2023
Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals. Methods. Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2. The results indicate that recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.
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Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes. Gemmati Donato, et al. Frontiers in genetics 2022 0 0. 1028081 |
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian families. Azzarà Alessia, et al. PloS one 2022 0 0. (10) e0275988 |
Genome Reporting for Healthy Populations-Pipeline for Genomic Screening from the GENCOV COVID-19 Study. Frangione Erika, et al. Current protocols 2022 0 0. (10) e534 |
Association of polygenic risk scores and hair cortisol with mental health trajectories during COVID lockdown. Ahrens Kira F, et al. Translational psychiatry 2022 0 0. (1) 396 |
Genetic risk and incident venous thromboembolism in middle-aged and older adults following COVID-19 vaccination. Xie Junqing, et al. Journal of thrombosis and haemostasis : JTH 2022 0 0. |
Polygenic Risk Scores for Asthma and Allergic Disease Predict COVID-19 Severity in 9/11 Responders M Wazczuk et al, MEDRXIV, August 31, 2022 |
Genetic predispositions to psychiatric disorders and the risk of COVID-19. Chen Wenwen, et al. BMC medicine 2022 0 0. (1) 314 |
Network Embedding Across Multiple Tissues and Data Modalities Elucidates the Context of Host Factors Important for COVID-19 Infection. Hu Yue, et al. Frontiers in genetics 2022 0 0. 909714 |
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19. Crossfield Samantha S R, et al. International journal of epidemiology 2022 0 0. |
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19. Rüter Jule, et al. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2022 0 0. |
Novel genes and sex differences in COVID-19 severity. Cruz Raquel, et al. Human molecular genetics 2022 0 0. |
Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam. Hoang Tham H, et al. BMC infectious diseases 2022 0 0. (1) 558 |
Colliding with Collider Bias: Implications for Precision Public Health D Rasooly et al, CDC Blog Post, May 9, 2022
Large-scale genomic studies have uncovered thousands of statistical associations between genetic variants and health outcomes, transforming our understanding of the genetic determinants of human diseases. Nevertheless, study sample selection and attrition over time can bias associations between variables, generating potentially biased estimates for genetic associations. This bias can be magnified in the case of studying phenotypic associations with polygenic risk scores in large scale cohort studies of unrepresentative or highly selected populations, such as the UK biobank, and potentially in the newly launched All of Us Research Program cohort study.
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Genetic risk and incident venous thromboembolism in middle-aged and older adults following 1 Covid-19 vaccination J Xie et al, MEDRXIV, April 18, 2022
Using data from the UK Biobank, which contains in-depth genotyping data and linked vaccination and health outcomes information, we generated a polygenic risk score (PRS) using 299 genetic variants identified from a previous large genome-wide association study. We prospectively assessed associations between PRS and incident VTE after first and the second-dose vaccination separately. The PRS was significantly associated with a higher risk of VTE (HR per 1 SD increase in PRS, 1.41 (95% CI 1.15 to 1.73) in 28 days and 1.36 (95% CI 1.22 to 1.52) in 90 days). Similar associations were found after stratification by vaccine type, in the two-dose cohort and across the historical unvaccinated cohorts.
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Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations. Marçalo Rui, et al. PloS one 2022 0 0. (2) e0264009 |
Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis. Byun Jinyoung, et al. Scientific reports 2022 0 0. (1) 1891 |
Association Between Genetic Predictors for C-Reactive Protein and Venous Thromboembolism With Severe Adverse Coronavirus Disease 2019 Outcomes. Guo Boya, et al. Critical care explorations 2021 0 0. (12) e0602 |
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity. Fallerini Chiara, et al. Human genetics 2021 0 0. |
MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity. Cappadona Claudio, et al. Journal of personalized medicine 2021 0 0. (11) |
PAGEANT: Personal Access to Genome and Analysis of Natural Traits Huang, Jie et al. medRxiv October 14 2021 |
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